Epitomax is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. In children, Epitomax is indicated for the treatment of Lennox-Gastaut syndrome, a disorder that causes seizures and developmental delay. Most often, it is prescribed for the prevention of migraines, it reduces the frequency of attacks.
Treatment of epilepsy
In a 2019 study comparing the effectiveness of epilepsy treatment between carbamazepine and Epitomax, the results showed that those who took carbamazepine were more likely to take treatment longer and achieved remission 12 months earlier than those who took Epitomax. No differences were found between the drugs in individuals with generalized or unclassified epilepsy.
The most common side effects reported by participants during the trials were fatigue,” needles and needles ” (tingling sensation), headache, gastrointestinal problems, and anxiety or depression. These side effects were reported by people taking Epitomax or carbamazepine about the same number of times. For people with focal seizures, the reliability of the evidence was rated as moderate or high. For a small number of people with generalized or unclassified seizures, data reliability was assessed as low or moderate.
In a 2019 study on the possibility of using Epitomax in juvenile myoclonic epilepsy, the results showed that Epitomax was better tolerated than valproate, but was not more effective than valproate. Epitomax also appeared to perform better than placebo, but this result was based on a small number of participants included. The quality of evidence from the included studies was very poor, and the results should be interpreted with caution.
In a 2014 study on the possibility of using Epitomax as an adjunct in pharmacoresistant epilepsy, the results showed that to reduce the number of seizures in drug‐resistant focal epilepsy, Epitomax when used with other drugs is three times more effective than placebo. However, the addition of Epitomax to the main treatment causes an increase in side effects, such as problems with coordination (ataxia) and concentration, dizziness, drowsiness, fatigue, nausea, “wrong thinking”, irritation or numbness of the skin (paresthesia) and weight loss.
The treatment of pain
A 2018 review found that Epitomax is not used for chronic low back pain. Epitomax does not act as a painkiller for diabetic neuropathy, the only neuropathic condition in which it has been properly tested.
In a 2017 study on the possibility of using Epitomax to treat essential tremor, the results showed that due to the very low and poor quality of evidence, the effect of Epitomax on daily activity, the risk of treatment failure, and side effects remains unclear.
One common use of Epitomax not for its intended purpose relates to the treatment of bipolar disorder. A review published in 2010 showed the benefit of Epitomax in treating symptoms of borderline personality disorder, but the authors noted that it is based on only one randomized controlled trial and requires additional trials.
Epitomax has been used to treat alcoholism. In the VA / DoD 2015 Guide to substance use disorders, Epitomax is noted as a” strong point ” in its recommendations for alcohol use disorders.